From Medicine to Skincare: The Real Roots of PDRN
PDRN (Polydeoxyribonucleotide) was not originally developed for cosmetics. It first gained recognition in the medical and pharmaceutical field through injectable products used for tissue repair, wound healing, and post-laser recovery. These products contained high-purity Salmon DNA and were used for their clinically proven skin regeneration effects.
While many skincare ingredients contribute to overall skin health, PDRN stands out for its specific regenerative function—a function that depends heavily on dose.
Why PDRN Entered Cosmetics
As interest in high-performance skincare grew, PDRN began to appear in cosmetic formulations:
- It fit into the trend of cosmeceuticals with clinical-level actives.
- It provided visible skin regeneration results.
To see visible result, PDRN needs to be in sufficient
amounts to trigger true cellular regeneration. In skincare, this often translates to formulas that contain 10,000
ppm (1%) or more.
Understanding Plant-Based PDRN in Skincare
In recent years, there has been growing interest in vegan or plant-based PDRN, often derived from natural sources.
However, it's important to note:
- Many plant-based PDRN materials contain only trace levels of DNA, often below 10 ppm (0.001%).
- In finished formulations, the total PDRN content may be too low to produce strong regenerative effects.
- These ingredients can still be effective for concept-focused skincare, but their intensity differ from that of high-purity salmon-based PDRN.
What Makes NATORI PDRN (Salmon) Different?
- Over 90% high-purity PDRN content
- Less smell
- Budget friendly
- Clinically safe proven
Summary Table:
NATORI PDRN vs. Plant PDRN
|
Category |
NATORI PDRN (Salmon) |
Plant PDRN |
|
Origin |
Salmon sperm DNA |
Botanical extract |
|
PDRN Content |
90%+ purified PDRN |
~0.001% |
|
Safety |
Proven safe |
Proven safe |
|
Clean Beauty |
✅ |
✅ |
|
Positioning |
High-performance, clinical-inspired skincare |
Botanical / vegan concept |
✅ “Same name, Different power – Don’t Just Compare, Understand.”
Conclusion:
High Concentration = Real Regeneration
The story of PDRN began with function, not concept.
It's reputation was built on results proven through high-dose clinical use.
For brands seeking visible skin regeneration, functional anti-aging, or post-treatment care, NATORI PDRN offers the concentration, purity, and proven mechanism to meet those goals—responsibly and effectively.
Frequently Asked Questions (FAQ)
❓Q1: Since Plant PDRN has a lower molecular weight, wouldn’t it be absorbed better?
It’s true that Plant PDRN may absorb faster due to its smaller molecular size.
However, what really matters is whether it has the structure and dosage required to activate regeneration pathways like the A2A receptor.
Most Plant PDRN ingredients contain only 0.001% Sodium DNA or less, which is far too low to induce a meaningful biological response.
In contrast, NATORI PDRN contains over 90% purified PDRN, delivering a concentration that can actually stimulate skin regeneration, anti-inflammatory effects, and tissue repair once absorbed.
❓Q2: Plant PDRN also shows skin regeneration effects in some studies. Isn’t that enough?
If a regeneration effect is shown, it's essential to look at the treatment conditions:
What concentration was used? How long was it applied? — often at relatively too high doses and long exposure times.
That’s why the regenerative effects seen in controlled lab settings may not translate into real consumer products.