Lumisome® RC is a next-generation depigmentation active featuring nano-encapsulated 4-Butylresorcinol delivered through a water-soluble liposomal system. This advanced delivery technology enables superior skin penetration, enhanced stability, and high whitening efficacy—even at low concentrations.
Designed for premium and dermocosmetic applications, Lumisome® RC addresses hyperpigmentation at multiple stages of melanogenesis while maintaining formulation flexibility.
Why 4-Butylresorcinol?
4-Butylresorcinol is recognized as one of the most potent tyrosinase inhibitors used in cosmetic formulations.
- IC50: 21 μmol/L
-
20× stronger than Kojic Acid
- Significantly more effective than Arbutin and Hydroquinone
This high potency allows formulators to achieve visible brightening results with lower active loading, improving safety margins and formulation elegance.
Key Technical Advantages of Lumisome® RC
Potent Tyrosinase Inhibition
Effectively suppresses melanin synthesis by inhibiting tyrosinase activity at very low concentrations.
Multi-Pathway Brightening Action
Targets pigmentation across pre-, during-, and post-melanogenesis, acting on:
- Tyrosinase
- TRP-1
- Melanin transfer pathways
Enhanced Stability Through Liposomal Encapsulation
The liposomal system protects 4-Butylresorcinol from oxidation, delivering:
- Improved shelf-life stability
- Consistent in-formula performance compared to conventional 4-BR
Water-Soluble & Formulation-Friendly
Nano-capture technology transforms an oil-soluble active into a hydrophilic ingredient, making it easy to incorporate into:
- Serums
- O/W and W/S emulsions
- Gel systems
Clinically Validated Performance
In vivo and in vitro studies demonstrate:
- Visible reduction of melasma and age spots
- Noticeable brightening within 4–8 weeks
Formulation Profile
- Recommended use level: 0.5–5.0%
- Active content: 20% 4-Butylresorcinol
- pH compatibility: 4.0–6.0
- Formulation types: O/W, W/S, gels formulations
Ideal Applications
- High-efficacy whitening serums
- Spot correctors
- Anti-melasma treatments
- Intensive brightening creams
- Premium and dermocosmetic skincare lines
Natori Lumisome RC - High-Performance Depigmentation Active
Looking to develop a high-efficacy brightening product with clinically proven performance Our technical team supports formulation design, stability guidance, and application trials using Lumisome® RC.
Read more: Natori Lumisome RC: Improved Rucinol for Skin Whitening
👉 Contact us to request technical data, formulation support, or sample evaluation.